microRNAs are small ~22 nucleotide non-coding RNAs that can bind protein coding mRNAs through complimentary base pairing to mediate mRNA decay or translational repression. Because a single microRNA can bind and silence hundreds of genes across diverse signaling pathways they can be developed as powerful therapeutic agents to silence entire disease networks. We have evidence to suggest that the mir-130 microRNA family can significantly enhance p53 expression in p53 functional tumors and cell lines along with inducing sensitivity to cisplatin a chemotherapeutic drug used to treat ovarian and a number of other cancers. Our work is currently focused on developing this microRNA family as an alternative or complement to small molecule inhibitors for cancer treatment.