We have invented a method of force-modulated hybridization for DNA/RNA detection and analysis, along with the associated device and consumables. The invention possesses three unique capabilities. First, it is able to measure nucleic acids with single-nucleotide length resolution, which has not been achieved with other methods. Second, it requires no amplification and no expensive instrument because the changes in measuring different samples can be visually observed via the color of magnetic labels. Third, a set of specific sample holders will streamline analysis and a simple device will quantify the results when needed.