Nanonetwork materials, so called nanosponges, have been generated by the crosslinking ofpendant functional groups such as epoxides with nucleophiles. The amount of pendant groups per chain and the amount of crosslinker governed size and network density control which were important factors to control the release of therapeutics. The nanonetwork allowed for a postloading with drugs, another advantage for the design of scalable drug delivery systems. Upon the success of the first generation of nanosponge delivery systems, we opted to develop an even more practical synthesis by incorporating crosslinking units into the backbone of the polymer chain rather than generating pendant functional groups through postmodification chemistries. We implemented a keto group into the polymer backbone which then facilitates a ketoxime bond with aminooxy groups which can be then reduced to an alkoxyamine bond in a consecutive one step procedure. The two different chemical connections generate two different release profiles designed to degrade faster in the tumor environment.