Turbulent secondary flows are naturally or artificially induced flows perpendicular to the main direction of primary flow. They are often induced in practical applications such as centrifugal mixers with curved-pipe systems and rotating machinery to enhance and optimize mixing of chemicals and other fluids. However, depending on how the secondary flow is generated, it may be ordered and stationary in space creating stagnant regions, which inhibits mixing even if the flow has significant turbulence. This technology focuses on using non-wetting (superhydrophobic) surfaces to control the secondary flows, ultimately enhancing the performance of centrifugal mixers. In particular, we pattern the solid boundaries of mixer is considered. By using a combination of direct numerical simulations (Computational Fluid Dynamics – CFD) and laboratory experiments, questions on which types and patterns of treatments are most effective for the secondary flows have been answered. The effectiveness of different kinds of surface treatments, both in the direction of the flow, and perpendicular to the flow is evaluated by measuring frictional losses and flow homogeneity. A wide variety of surface patterns are tested to determine the most efficient arrangements by using boundary conditions that resemble both ideal and real treatments. Experiments have measured the real-world efficacy of these treatments with great precision. Finally, by studying aging surfaces, the lifetime of the treatment effectiveness is estimated.