NRL Long Range Broad Agency Announcement (BAA) for Basic and Applied Research
Sponsored by: Naval Research Laboratory
Deadline: FY2025 announcement expected in March 2025
Description: The Naval Research Laboratory (NRL) is the Navy's corporate laboratory. NRL conducts basic and applied research for the Navy in a variety of scientific and technical disciplines. The research conducted at NRL is a broadly based multidisciplinary program of scientific research and advanced technological development directed toward maritime applications of new and improved materials, techniques, equipment, systems and ocean, atmospheric, and space sciences and related technologies. Although NRL conducts most of its research programs within NRL facilities and associated warfare centers, NRL intends to fund research conducted with educational facilities and industry partners which are related to specific topics included in this BAA announcement.

Young Faculty Award (YFA)
Sponsored by: Defense Advanced Research Projects Agency (DARPA), Defense Sciences Office (DSO)
Deadline: Next competition expected November 2025
Description: The YFA aims to identify and engage rising stars in junior research positions in academia and
equivalent positions at non-profit research institutions, particularly those without prior DARPA
funding, to expose them to Department of Defense (DoD) needs and DARPA’s mission to create
and prevent technological surprise. The YFA program will provide high-impact funding to elite
researchers early in their careers to develop innovative new research that enables transformative
DoD capabilities. Ultimately, the YFA program is developing the next generations of researchers
focused on national security issues.

ARO - Defense University Research Instrumentation Program (DURIP)
Solicitation: W911NF25S0003
Sponsored by: Dept of the Army -- Materiel Command
Deadline: April 25, 2025
Description: DURIP is designed to improve the capabilities of accredited United States (U.S.) institutions of higher education to conduct research and to educate scientists and engineers in areas important to national defense, by providing funds for the acquisition of research equipment or instrumentation.

AFOSR - Defense University Research Instrumentation Program (DURIP)
Solicitation: NOFOAFRLAFOSR20250005
Sponsored by: Air Force Office of Scientific Research
Deadline: April 25, 2025
Description: DURIP is designed to improve the capabilities of accredited United States (U.S.) institutions of higher education to conduct research and to educate scientists and engineers in areas important to national defense, by providing funds for the acquisition of research equipment or instrumentation.

ONR - Defense University Research Instrumentation Program (DURIP)
Solicitation: N0001425SF001
Sponsored by: Office of Naval Research
Deadline: April 25, 2025
Description: DURIP is designed to improve the capabilities of accredited United States (U.S.) institutions of higher education to conduct research and to educate scientists and engineers in areas important to national defense, by providing funds for the acquisition of research equipment or instrumentation.

Research and Education Program for Historically Black Colleges and Universities and Minority-Serving Institutions (HBCU/MI)
Solicitation: W911NF24S0009
Sponsored by: Dept of the Army -- Materiel Command
Deadline: Continually accepted through July 31, 2029
Description: Projects proposed for funding under this FOA include all scientific study and experimentation directed toward increasing fundamental knowledge and understanding in those fields of the physical, engineering, environmental, life sciences, and information sciences related to long-term national security needs. PIs are encouraged to consider innovative approaches for their research projects with a view toward enhancing the ability of their institution to develop stronger science and engineering programs that will enable the institution to participate more competitively in a variety of defense research programs, attract and retain good students by exposing them to state-of-the-art research, and encourage them to pursue careers in STEM disciplines.

NEW All ARPA-E Funding Opportunities
Solicitation Number: multiple
Deadline: varies by FOA
Description: ARPA-E aims to radically improve US standing in the global energy landscape while bringing energy manufacturing back home to support local communities. ARPA-E focuses on diverse technologies that can be meaningfully advanced with a small amount of funding and active project management over a defined period of time. Our streamlined awards process enables us to act quickly to drive disruption across the entire energy portfolio.

Spurring Projects to Advance Energy Research and Knowledge Swiftly (SPARKS) (DOE ARPA-E)
Solicitation Number: DE-FOA-0003164
Deadline: Proposals are accepted at any time
Description: This program provides a continuing opportunity for the rapid support of early-stage applied research to explore innovative new concepts with the potential for transformational and disruptive changes in energy technology. SPARKS awards are intended to be flexible and may take the form of analyses or exploratory research that provides the agency with useful information for the subsequent development of focused technology programs. SPARKS awards may also support proof-of-concept research to develop a unique technology concept, either in an area not currently supported by the agency or as a potential enhancement to an ongoing focused technology program.

FY2025 Continuation of Solicitation for the Office of Science Financial Assistance Program
Solicitation Number: DE-FOA-0003432
Deadline: Proposals continuously accepted through Sep 30, 2025
Description: The Office of Science hereby announces its continuing interest in receiving grant applications for support of work in the following program areas: Advanced Scientific Computing Research, Basic Energy Sciences, Biological and Environmental Research, Fusion Energy Sciences, High Energy Physics, Nuclear Physics, Isotope R&D and Production, and Accelerator R&D and Production. There is also an early career track.

Research Opportunities in Space and Earth Science (ROSES)-2024
Solicitation Number: NNH24ZDA001N
Deadline: varies by program
Description: ROSES-2024 is an omnibus NASA Research Announcement. It contains over 100 different proposal opportunities. See Table 2: Solicited Research Programs for the full list of opportunities.

ENGAGEMENT OPPORTUNITIES IN NASA STEM FY2024 (EONS-2024)
Solicitation Number: NNH24ZHA003C
Deadline: Sep 30, 2026
Description: The NASA OSTEM MUREP Program solicits proposals from 4-year colleges/universities designated by the U.S. Department of Education as MSIs for the MUREP Institutional Research Opportunity (MIRO) activity. MIRO develops significant scientific, engineering, and/or technology research centers. The purpose of MIRO is to strengthen and develop the research capacity and infrastructure of MSIs in areas of strategic importance and value to NASA’s mission and priorities. MIRO awards promote STEM literacy and enhance and sustain the capability of institutions to perform NASA-related research and education. Additionally, MIRO strengthens student participation in research at MSIs in order to develop and diversify the next generation of the STEM workforce. MIRO awards directly support research pertinent to NASA’s five Mission Directorates (MDs) – Aeronautics Research, Exploration Systems Development, Space Operations, Science, and Space Technology.

Computer and Information Science and Engineering (CISE): Core Programs, Large Projects
Solicitation Number: NSF 24-572
Deadline: September 29, 2025; September 28, 2027
Description: The NSF CISE Directorate supports research and education projects that develop new knowledge in all aspects of computing, communications, and information science and engineering through core programs. The core programs for the participating CISE divisions invites proposals on bold new scientific ideas tackling ambitious fundamental research problems that cross the boundaries of two or more core programs. These problems must be well suited to large-scale integrated collaborative efforts. Teams should consist of two or more investigators PIs with complementary expertise.

Advanced Technological Education (ATE)
Solicitation Number: NSF 24-584
Deadline: First Thursday in October, annually
Description: This program supports the education of technicians for the high-technology fields that drive our nation's economy. The program involves partnerships between academic institutions (grades 7-12, IHEs), industry, and economic development agencies to promote improvement in the education of science and engineering technicians. It is strongly recommended that projects be faculty-led and required that courses and programs are credit-bearing, although materials developed may also be used for incumbent worker education.

Mid-scale Research Infrastructure-1 (Mid-scale RI-1)
Solicitation Number: NSF 24-598
Deadline: Prelim Proposal: September 01, 2026; Full proposal: February 08, 2027
Description: This program supports an agile, Foundation-wide process to fund experimental research capabilities in the mid-scale range between MRI and Major Multi-user Facilities. Mid-scale RI-1 supports either design activities or implementation of unique and compelling RI projects. Mid-scale implementation projects may include any combination of equipment, instrumentation, cyberinfrastructure, broadly used large scale datasets and the personnel needed to successfully commission the project.

Advancing Informal STEM Learning (AISL)
Solicitation Number: NSF 24-601
Deadline: January 14, 2026; Second Wednesday in January, Annually Thereafter
Description: This program is committed to funding research and practice, with continued focus on investigating a range of informal STEM learning experiences and environments that make lifelong learning a reality. This program seeks proposals that center engagement, broadening participation, and belonging, and further the well-being of individuals and communities who have been and continue to be excluded, underserved, or underrepresented in STEM along several dimensions. The current solicitation encourages proposals from institutions and organizations that serve public audiences, and specifically focus on public engagement with and understanding of STEM, including community STEM; public participation in scientific research; science communication; intergenerational STEM engagement; and STEM media.

Mathematical Foundations of Digital Twins
Solicitation Number: NSF 24-559
Deadline: March 17, 2025; March 15, Annually Thereafter
Description: The Division of Mathematical Sciences (DMS) in the Directorate for Mathematical and Physical Sciences (MPS) at the National Science Foundation (NSF) and the Air Force Office of Scientific Research (AFOSR) plan to jointly support foundational mathematical and statistical research on Digital Twins in applied sciences. Recent years have witnessed a significant increase in the demand and interest in applications that involve collaborative teams developing and analyzing Digital Twins to support decision making in various fields, including science, engineering, medicine, urban planning, and more. Both agencies recognize the need to promote research aiming to stimulate an interplay between mathematics/statistics/computation and practical applications in the realm of Digital Twins. This program encourages new collaborative efforts within the realm of Digital Twins, aiming at stimulating fundamental research innovation, pushing, and expanding the boundaries of knowledge, and exploring new frontiers in mathematics and computation for Digital Twin development, and its applications. By leveraging this synergy, the program aims to harness science, technology, and innovation to address some of our Society's most pressing challenges.

Foundations for Digital Twins as Catalyzers of Biomedical Technological Innovation
Solicitation Number: NSF 24-561
Deadline: May 05, 2025; First Monday in May, Annually Thereafter
Description: The Foundations for Digital Twins as Catalyzers of Biomedical Technological Innovation (FDT-BioTech) program supports inherently interdisciplinary research projects that underpin the mathematical and engineering foundations behind the development and use of digital twins and synthetic data in biomedical and healthcare applications, with a particular focus on digital, in silico models used in the evaluation of medical devices and the relevance of the developed models in addressing current and emerging challenges affecting the development and assessment of biomedical technologies. The goal of the FDT-BioTech initiative is to catalyze biomedical technological innovation through new foundational development of methods and algorithms relevant to digital twins and synthetic humans.

Artificial Intelligence, Formal Methods, and Mathematical Reasoning
Solicitation Number: NSF 24-554
Deadline: February 05, 2026
Description: The Artificial Intelligence, Formal Methods, and Mathematical Reasoning (AIMing) program seeks to support research at the interface of innovative computational and artificial intelligence (AI) technologies and new strategies/technologies in mathematical reasoning to automate knowledge discovery. Mathematical reasoning is a central ability of human intelligence that plays an important role in knowledge discovery. In the last decades, both the mathematics and computer science communities have contributed to research in machine-assisted mathematical reasoning, encompassing conjecture, proof, and verification. This has been in the form of both formal methods and interactive theorem provers, as well as using techniques from artificial intelligence. Recent technological advances have led to a surge of interest in machine-assisted mathematical reasoning from the mathematical sciences, formal methods, and AI communities. In turn, advances in this field have potential impact on research in AI.

Improving Undergraduate STEM Education: Computing in Undergraduate Education
Solicitation Number: NSF 24-553
Deadline: April 29, 2025; Last Tuesday in April, Annually Thereafter
Description: The Improving Undergraduate STEM Education: Computing in Undergraduate Education (IUSE: CUE) program aims to better prepare a wider, more diverse range of students to collaboratively use computation across a range of contexts and challenging problems. With this solicitation, the National Science Foundation focuses on re-envisioning how to teach computing effectively to a broad group of students, in a scalable manner, with an emphasis on broadening participation of groups who are underrepresented and underserved by traditional computing courses and careers.

Partnerships in Astronomy & Astrophysics Research and Education (PAARE)
Solicitation Number: NSF 24-516
Deadline: February 15, Annually Thereafter
Description: The objective of PAARE is to improve the quality and environment of astronomy and astrophysics research and education by stimulating the development of formal, long-term partnerships that provide authentic pathways into the research enterprise and broaden participation in astronomy by encouraging proposals from the full spectrum of talent across society to include individuals from groups that have been historically underrepresented. Partnerships must substantially involve institutions seeking to create opportunities for student and faculty research that will increase the recruitment, retention, and success of these individuals. It is expected that the partnerships will build or strengthen research capacity, as well as foster a diverse, inclusive, and equitable environment for astronomy and astrophysics research and education at the partnering institutions.

Partnerships for Research Innovation in the Mathematical Sciences (PRIMES)
Solicitation Number: NSF 24-517
Deadline: February 12, 2025; 2nd Wednesday in February, Annually Thereafter; August 20, 2025; 3rd Wednesday in August, Annually Thereafter
Description: The NSF Division of Mathematical Sciences’ Partnerships for Research Innovation in the Mathematical Sciences program aims to enhance partnerships between minority-serving institutions and DMS-supported Mathematical Sciences Research Institutes. The activity seeks to boost the participation of members of groups underrepresented in the mathematical sciences through their increased involvement in research programs at the institutes.

Partnership to Advance Conservation Science and Practice (PACSP)
Solicitation Number: NSF 25-524
Deadline: March 17, 2025
Description: The objective of the PACSP Program is to support conservation research that investigates organismal biology, ecology, and/or evolution and is designed to contribute to the development and implementation of evidence-based activities and/or technology solutions to advance biodiversity conservation. We seek proposals that involve the implementation of conservation activities based on conservation science principles via academic-conservation organization partnerships. The strongest projects will involve ongoing assessment of biodiversity outcomes, for instance via an adaptive management framework, that inform both scientific understanding and conservation actions. A significant distinction between the PACSP program and other NSF programs is that proposals to this program must make clear and well-defined connections between basic research questions and the implementation of conservation focused actions.

Ecosystem for Leading Innovation in Plasma Science and Engineering (ECLIPSE)
Solicitation Number: NSF 24-503
Deadline: due dates vary by division
Description: Plasma science is a transdisciplinary field of research where fundamental studies in many disciplines, including plasma physics, plasma chemistry, materials science, and space science, come together to advance knowledge for discovery and technological innovation. The primary goal of the ECosystem for Leading Innovation in Plasma Science and Engineering (ECLIPSE) program is to identify and capitalize on opportunities for bringing fundamental plasma science investigations to bear on problems of societal and technological need within the scope of science and engineering supported by the participating NSF programs.

Research Experiences for Teachers (RET) in Engineering and Computer Science
Solicitation Number: NSF 24-503
Deadline: Second Wednesday in October, Annually
Description: This program supports authentic summer research experiences for K-14 educators to foster long-term collaborations between universities, community colleges, school districts, and industry partners. With this solicitation, the Directorates for Engineering and Computer and Information Science and Engineering focus on a reciprocal exchange of expertise between K-14 educators and research faculty and (when applicable) industry mentors. K-14 educators will enhance their scientific disciplinary knowledge in engineering or computer science and translate their research experiences into classroom activities and curricula.

International Research Experiences for Students (IRES)
Solicitation Number: NSF 24-506
Deadline: October 28, 2024; Fourth Monday in October, Annually Thereafter
Description: The IRES program supports international research and research-related activities for U.S. science and engineering students. The IRES program contributes to development of a diverse, globally engaged workforce with world-class skills. IRES focuses on active research participation by undergraduate and/or graduate students in high quality international research, education and professional development experiences in NSF-funded research areas.

Designing Synthetic Cells Beyond the Bounds of Evolution (Designer Cells)
Solicitation Number: NSF 24-505
Deadline: Feb 1, 2026; Feb 1 2028
Description: The goal of this solicitation is to support research that (1) develops cell-like systems to identify the minimal requirements for the processes of life, (2) designs synthetically-modified cells to address fundamental questions in the evolution of life or to explore biological diversity beyond that which currently exists in nature, and (3) leverages basic research in cell design to build novel synthetic cell-like systems and cells for innovative biotechnology applications. Highest funding priority is given to proposals that have outstanding intellectual merit and broader impacts, while proposals with weaknesses in either category (or those that are perceived as likely to have an incremental impact) will not be competitive.

Ethical and Responsible Research (ER2)
Solicitation Number: NSF 24-604
Deadline: 4th Thursday in January, annually
Description: The ER2 program encourages research that generates an improved understanding of how and why research approaches, practices and norms foster or hinder ethics education and training of science, technology, engineering and mathematics (STEM) researchers and practitioners. The program aims to support the formation, improvement and dissemination of ethical research practices in STEM fields and to foster organizational cultures that value and reward academic and research integrity. The program also seeks to motivate, inform and educate STEM researchers, including undergraduate and graduate students, postdoctoral fellows and faculty, to identify and explore the ethical dimensions of research so that their work is responsive to the needs and values of society.

Accelerating Research through International Network-to-Network Collaborations (AccelNet)
Solicitation Number: NSF 23-619
Deadline: 3rd Monday in September, Annually
Description: The contemporary research landscape is a collaborative and international enterprise requiring high level coordination among multi-disciplinary, cross-cultural teams. As such, the Accelerating Research through International Network-to-Network Collaborations program (AccelNet) values cooperation over competition. Program goals are to 1) leverage prior NSF support for building research capacity towards activities that launch international research network of networks (NoN) that will lead to an accelerated advancement of an area of science after the award period and 2) recruit and foster a diverse and internationally competent US-based workforce trained in conducting and leading multi-team international collaboration. Successful proposals will demonstrate that the proposed activities will: 1) accelerate scientific research at a rate that would not be possible without concerted international cooperation in research planning; 2) make NoN members more competitive for research awards following the period of award; 3) recruit and foster a US-based diverse and internationally competent workforce trained in conducting and leading multi-team international collaboration. Proposals must include detailed plans for collaborative networking activities that will result in a synergy of effort across the entire NoN.

Focused Research Groups in the Mathematical Sciences (FRGMS)
Solicitation Number: waiting for new FOA
Deadline: TBA
Description: The purpose of the Focused Research Group activity is to support collaborative groups employing innovative methods to solve specific, major research challenges in the mathematical sciences. A major challenge is an outstanding problem of significant importance that requires the focused and synergistic efforts of a collaborative group to solve, and whose solution will have wide impacts in the mathematical sciences and potentially in other areas.

Catalysis
Solicitation Number: PD 23-1401
Deadline: Proposals accepted anytime
Description: The goals of the Catalysis program are to increase fundamental understanding in catalytic engineering science and to advance the development of catalysts and catalytic reactions that are beneficial to society. Research should focus on critical challenges and opportunities in both new and proven catalysis technologies. Areas of emphasis may include novel catalyst compositions, structures, operating environment, data science tools, theory, and modeling – preferably in various combinations as dictated by the specific reaction and related knowledge and technology gaps. Target applications include fuels, specialty and bulk chemicals, environmental catalysis, biomass conversion to fuels and chemicals, greenhouse gas mitigation, recycling of waste materials, generation of solar hydrogen, as well as efficient routes to energy utilization.

Mathematical Sciences Research Institutes
Solicitation Number: NSF 23-606
Deadline: March 14, 2029
Description: Mathematical Sciences Research Institutes are national resources that aim to advance research in the mathematical sciences through programs supporting discovery and dissemination of knowledge in mathematics and statistics and enhancing connections to related fields in which the mathematical sciences can play important roles. Institute activities help focus the attention of some of the best mathematical minds on problems of particular importance and timeliness. Institutes are also community resources that involve a broad segment of U.S.-based mathematical sciences researchers in their activities. The goals of the Mathematical Sciences Research Institutes program include advancing research in the mathematical sciences, increasing the impact of the mathematical sciences in other disciplines, and expanding the talent base engaged in mathematical research in the United States.

National Science Foundation Research Traineeship (NRT) Program
Solicitation Number: NSF 24-597
Deadline: November 14, 2024; September 08, 2025; September 8, Annually Thereafter
Description: This program seeks proposals that explore ways for graduate students in research-based master’s and doctoral degree programs to develop the skills, knowledge, and competencies needed to pursue a range of STEM careers. The program is dedicated to effective training of STEM graduate students in high priority interdisciplinary or convergent research areas, through a comprehensive traineeship model that is innovative, evidence-based, and aligned with changing workforce and research needs.

Research Training Groups in the Mathematical Sciences (RTG)
Solicitation Number: NSF 24-570
Deadline: August 12, 2025; 2nd Tuesday in August
Description: The long-range goal of the Research Training Groups in the Mathematical Sciences program is to strengthen the nation's scientific competitiveness by increasing the number of well-prepared U.S. citizens, nationals, and permanent residents who pursue careers in the mathematical sciences, be they in academia, government, or industry. The RTG program supports efforts to improve research training by involving undergraduate students, graduate students, postdoctoral associates, and faculty members in structured research groups pursuing coherent research programs. Research groups supported by RTG must include vertically-integrated activities that span the entire spectrum of educational levels from undergraduates through postdoctoral associates.

Centers of Research Excellence in Science and Technology (CREST Centers)
Solicitation Number: NSF 23-595
Deadline: Preliminary proposals (required): 1st Friday in December; Full applications: 1st Friday in December
Description: CREST Center awards provide support to enhance the research capabilities of Minority-serving institutions (MSIs) through the establishment of centers that effectively integrate education and research. CREST Center awards promote the development of new knowledge, enhancements of the research productivity of individual faculty, and an expanded presence of students historically underrepresented in science, technology, engineering, and mathematics (STEM) disciplines. Successful CREST Center proposals will demonstrate a clear vision and integration of STEM research and education and will align with the mission of the Division of Equity for Excellence in STEM (EES) with respect to the development of a diverse STEM workforce. CREST Centers are also expected to provide leadership by meaningfully involving the efforts of those faculty, students, and postdoctoral researchers who are traditionally underrepresented in STEM at all levels. Centers are required to use evidence-based and innovative strategies to address salient broadening participation and workforce development issues, such as recruitment, retention, and mentorship of participants from underrepresented groups. Successful proposals are expected to achieve national research competitiveness, broaden participation in STEM, and generate sustained, non-CREST funding from federal, state, and/or private-sector sources.

CyberCorps(R) Scholarship for Service (SFS)
Solicitation Number: NSF 23-574
Deadline: July 15, Annually
Description: The goals of the CyberCorps® Scholarship for Service (SFS) program are aligned with the U.S. strategy to develop a superior cybersecurity workforce. The program goals are to: (1) increase the number of qualified and diverse cybersecurity candidates for government cybersecurity positions; (2) improve the national capacity for the education of cybersecurity professionals and research and development workforce; (3) hire, monitor, and retain high-quality CyberCorps® graduates in the cybersecurity mission of the Federal Government; and (4) strengthen partnerships between institutions of higher education and federal, state, local, and tribal governments. While all three agencies work together on all four goals, NSF’s strength is in the first two goals; OPM’s in goal (3); and DHS in goal (4). The SFS Program welcomes proposals to establish or to continue scholarship programs in cybersecurity. A proposing institution must provide clearly documented evidence of a strong existing academic program in cybersecurity.

Thermal Transport Processes (TTP)
Solicitation Number: PD-23-1406
Deadline: Continuously accepted
Description: The Thermal Transport Processes program supports engineering research projects that lay the foundation for new advances in thermal transport phenomena. These projects should either develop new fundamental knowledge or combine existing knowledge in thermodynamics, fluid mechanics, and heat and mass transfer to probe new areas of innovation in thermal transport processes. The program seeks transformative projects with the potential for improving basic understanding, predictability and application of thermal transport processes.

NSF Scholarships in Science, Technology, Engineering, and Mathematics Program (S-STEM)
Solicitation Number: NSF 25-514
Deadline: March 04, 2025; 1st Tuesday in March, Annually Thereafter
Description: The main goal of the S-STEM program is to enable low-income students with academic ability, talent or potential to pursue successful careers in promising STEM fields. Ultimately, the S-STEM program seeks to increase the number of academically promising low-income students who graduate with a S-STEM eligible degree and contribute to the American innovation economy with their STEM knowledge. The S-STEM program encourages collaborations, including but not limited to partnerships among different types of institutions; collaborations of S-STEM eligible faculty, researchers, and academic administrators focused on investigating the factors that affect low-income student success (e.g., institutional, educational, behavioral and social science researchers); and partnerships.

Training-based Workforce Development for Advanced Cyberinfrastructure
Solicitation Number: NSF 23-520
Deadline: January 15, 2026; 3rd Thursday in January, Annually
Description: This program seeks to prepare, nurture, and grow the national scientific research workforce for creating, utilizing, and supporting advanced cyberinfrastructure to enable and potentially transform fundamental science and engineering research and education and contribute to the Nation's overall economic competitiveness and security.

Division of Molecular and Cellular Biosciences Core Programs (MCB)
Solicitation Number: NSF 24-539
Deadline: Proposals Accepted Anytime
Description: MCB supports research that promises to uncover the fundamental properties of living systems across atomic, molecular, subcellular, and cellular scales. The program gives high priority to projects that advance mechanistic understanding of the structure, function, and evolution of molecular, subcellular, and cellular systems, especially research that aims at quantitative and predictive knowledge of complex behavior and emergent properties. MCB encourages research exploring new concepts in molecular and cellular biology, while incorporating insights and approaches from other scientific disciplines, such as chemistry, computer science, engineering, mathematics, and physics, to illuminate principles that govern life at the molecular and cellular level. MCB also encourages research that exploits experimental and theoretical approaches and utilizes a diverse spectrum of model and non-model animals, plants, and microbes across the tree of life. Proposals that pursue potentially transformative ideas are welcome, even if these entail higher risk.

EDU Core Research: Building Capacity in STEM Education Research (ECR: BCSER)
Solicitation Number: NSF 22-548
Deadline: 4th Friday in February, Annually
Description: ECR’s Building Capacity in STEM Education Research (ECR: BCSER) supports projects that build investigators’ capacity to carry out high-quality STEM education research that will enhance the nation’s STEM education enterprise. In addition, ECR: BCSER seeks to broaden the pool of researchers who can advance knowledge regarding STEM learning and learning environments, broadening participation in STEM fields, and STEM workforce development. Specifically, ECR: BCSER supports activities that enable researchers to expand their areas of expertise and acquire the requisite knowledge and skills to conduct rigorous research in STEM education. Career development may be accomplished through investigator-initiated professional development and research projects or through institutes that enable researchers to integrate methodological strategies with theoretical and practical issues in STEM education.

Oceanographic Facilities and Equipment Support
Solicitation Number: NSF 23-525
Deadline: January 10th, annually
Description: These awards are made for the procurement, conversion and/or upgrade, enhancement, or annual operation of platforms in the ocean, coastal and near-shore waters, and Great Lakes. Awards are generally directed specifically to support facilities that lend themselves to shared use within the broad range of Federally supported research and education programs. The primary objective of these awards is to ensure the availability of appropriate oceanographic facilities for Federally funded investigators and educators.

Major Research Instrumentation Program (MRI)
Solicitation Number: NSF 23-519
Deadline: November 15, 2024; November 14, 2025; November 16, 2026
Description: Supports requests for up to $4 million from NSF for the development or acquisition of multi-user research instruments that are critical to the advancement of science and engineering. Track 1: $100,000 - $1,400,000; Track 2: $1,400,000 - $4,000,000; Track 3: $100,000 - $4,000,000 that include the purchase, installation, operation, and maintenance of equipment and instrumentation to conserve or reduce the consumption of helium. Institutions may submit no more than one Track 3 proposal.

Statistics
Solicitation Number: PD 18-1269
Deadline: December 1 - December 15, Annually
Description: The Statistics Program supports research in statistical theory and methods, including research in statistical methods for applications to any domain of science and engineering. The theory forms the base for statistical science. The methods are used for stochastic modeling, and the collection, analysis and interpretation of data. The methods characterize uncertainty in the data and facilitate advancement in science and engineering. The Program encourages proposals ranging from single-investigator projects to interdisciplinary team projects.

Improving Undergraduate STEM Education: Directorate for STEM Education (IUSE: EDU)
Solicitation Number: NSF 23-510
Deadline: Level 1: Third Wednesday in January; Level 2 and 3: Third Wednesday in July, Annually
Description: This is a core NSF STEM education program that seeks to promote novel, creative, and transformative approaches to generating and using new knowledge about STEM teaching and learning to improve STEM education for undergraduate students. The program is open to application from all institutions of higher education and associated organizations. NSF places high value on educating students to be leaders and innovators in emerging and rapidly changing STEM fields as well as educating a scientifically literate public.

Expanding AI Innovation through Capacity Building and Partnerships (ExpandAI)
Solicitation Number: NSF 23-506
Deadline: October 18, 2024; March 10, 2025; June 23, 2025; October 17, 2025
Description: The National Science Foundation and its partners support the continued growth of a broad and diverse interdisciplinary research community for the advancement of AI and AI-powered innovation, providing a unique opportunity to broadly promote the NSF vision and core values, especially inclusion and collaboration. The Expanding AI Innovation through Capacity Building and Partnerships (ExpandAI) program aims to significantly broaden participation in AI research, education, and workforce development through capacity development projects and through partnerships within the National AI Research Institutes ecosystem.

Build and Broaden: Enhancing Social, Behavioral and Economic Science Research and Capacity at Minority-Serving Institutions (B2)
Solicitation Number: NSF 25-505
Deadline: Third Thursday in January, Annually
Description: Build and Broaden (B2) supports fundamental research and research capacity across disciplines at MSIs and encourages research collaborations with scholars at MSIs. Growing the STEM workforce is a national priority. Proposals are invited from single principal investigators based at MSIs and from multiple co-investigators from groups of MSIs. Principal investigators who are not affiliated with MSIs may submit proposals, but must collaborate with PIs, co-PIs, or senior personnel from MSIs.

Paleo Perspectives on Present and Projected Climate (P4CLIMATE)
Solicitation Number: NSF 22-612
Deadline: October 20, Annually
Description: The PALEO PERSPECTIVES ON PRESENT AND PROJECTED CLIMATE (P4CLIMATE) competition is a coordinated paleoclimate science initiative that is funded by the National Science Foundation (NSF) Divisions of Atmospheric and GeoSpace Sciences (AGS), Earth Sciences (EAR), Ocean Sciences (OCE), and Office of Polar Programs (OPP) in the Geosciences (GEO) Directorate. The annual P4CLIMATE competition supports the scientific objectives of the National Science Foundation by fostering interdisciplinary research and synthesis of climate data. The goal of the interdisciplinary P4CLIMATE solicitation is to utilize observational and modeling studies to provide paleo perspectives addressing the two research themes: 1) Past Regional and Seasonal Climate; and 2) Past Climate Forcing, Sensitivity, and Feedbacks.

Computer and Information Science and Engineering: Core Programs
Solicitation Number: NSF 24-589
Deadline: OAC Core Projects and MEDIUM Projects: Dec 1–Dec 22, Annually; Small Projects: Oct 1–Sep 30, Annually
Description: The NSF CISE Directorate supports research and education projects that develop new knowledge in all aspects of computing, communications, and information science and engineering, as well as advanced cyberinfrastructure, through a variety of core programs.

Computer and Information Science and Engineering (CISE): Core Programs, Large Projects
Solicitation Number: NSF 24-572
Deadline: September 29, 2025; September 28, 2027
Description: This solicitation invites proposals on bold new ideas tackling ambitious and fundamental research problems within scope of one or more of the participating CISE divisions core programs listed above, and that are well suited to a large-scale integrated collaborative effort. Teams should consist of two or more investigators (PI, co-PI(s), or other Senior Personnel) with complementary expertise. Investigators are strongly encouraged to come together within or across disciplines and/or institutions and combine their creative talents to identify compelling, transformative research agendas where the impact of the results will exceed that of the sum of each of their individual contributions. Investigators are especially encouraged to seek out partnerships in a wide class of institutions that together produce innovative approaches to the proposed research. Proposals that are focused on research infrastructure are not appropriate for this solicitation. Proposers are invited to submit proposals with total budgets from $3,000,000 to $5,000,000 and durations up to five years.

NSF's Eddie Bernice Johnson Inclusion across the Nation of Communities of Learners of Underrepresented Discoverers in Engineering and Science (INCLUDES) Initiative
Solicitation Number: NSF 22-622
Deadline: Conferences: May 13, 2025 (2nd Tuesday in May); Network Connectors/Alliances: Oct 28, 2025 (4th Tuesday in Oct)
Description: NSF INCLUDES seeks to motivate and accelerate collaborative infrastructure building to advance equity and sustain systemic change to broaden participation in STEM fields at scale. Significant advancement in the inclusion of groups that have historically been excluded from or underserved in STEM will result in a new generation of STEM talent and leadership to secure the Nation’s future and long-term economic competitiveness. NSF offers support for five types of projects that connect and contribute to the National Network: (1) Design and Development Launch Pilots, (2) Collaborative Change Consortia, (3) Alliances, (4) Network Connectors, and (5) Conferences. The NSF INCLUDES National Network is a multifaceted collaboration of agencies, organizations, and individuals working collectively to broaden participation in STEM.

Advanced Technologies and Instrumentation for the Astronomical Sciences (ATI)
Solicitation Number: NSF 22-627
Deadline: Nov 15, annually
Description: This program provides individual investigator and collaborative research grants for the development of new technologies and instrumentation for use in ground-based astronomy and astrophysics. The program supports achieving the science objectives of the Division of Astronomical Sciences. The development of innovative, potentially transformative, technologies and instruments are sought, even at high technical risk.

Mathematical Biology (NSF)
Solicitation Number: PD 22-7334
Deadline: Oct 14, 2025
Description: The Mathematical Biology Program supports research in areas of applied and computational mathematics with relevance to the biological sciences. Successful proposals must demonstrate mathematical innovation, biological relevance and significance, and strong integration between mathematics and biology.

Division of Chemistry: Disciplinary Research Programs (CHE-DRP)
Solicitation Number: NSF 22-605
Deadline: CAT, CSDM-B, SYN: Sep 1 - Sep 30, annually; CMI, ECS, MSN: Oct 1-Oct 31, annually
Description: This solicitation applies to six (of the nine) CHE Disciplinary Research Programs: Chemical Catalysis (CAT); Chemical Measurement and Imaging (CMI); Chemical Structure Dynamics and Mechanisms-B (CSDM-B); Chemical Synthesis (SYN); Environmental Chemical Sciences (ECS); and Macromolecular, Supramolecular and Nanochemistry (MSN).

Division of Chemistry: Disciplinary Research Programs: No Deadline Pilot (CHE-DRP:NDP)
Solicitation Number: NSF 22-606
Deadline: Proposals Accepted Anytime
Description: With this solicitation, the Division of Chemistry is piloting the removal of deadlines for the submission of proposals to the CLP, CSDM-A and CTMC Programs. The no-deadline pilot seeks to assess the benefits and challenges of removing deadlines in proposal submission for the chemistry research community: the removal of deadlines on proposal submission is intended to allow principal investigators (PIs) more flexibility and better facilitate interdisciplinary research. It may, however, have unanticipated consequences for PIs, reviewers, and institutions.

Condensed Matter and Materials Theory
Solicitation Number: NSF 23-611
Deadline: proposals accepted anytime
Description: CMMT supports theoretical and computational materials research in the topical areas represented in DMR's other Topical Materials Research Programs (these are also variously known as Individual Investigator Award (IIA) Programs, or Core Programs, or Disciplinary Programs), which are: Condensed Matter Physics (CMP), Biomaterials (BMAT), Ceramics (CER), Electronic and Photonic Materials (EPM), Metals and Metallic Nanostructures (MMN), Polymers (POL), and Solid State and Materials Chemistry (SSMC). The CMMT program supports fundamental research that advances conceptual understanding of hard and soft materials, and materials-related phenomena; the development of associated analytical, computational, and data-centric techniques; and predictive materials-specific theory, simulation, and modeling for materials research. First-principles electronic structure, quantum many-body and field theories, statistical mechanics, classical and quantum Monte Carlo, and molecular dynamics, are among the methods used in the broad spectrum of research supported in CMMT.

Division of Materials Research: Topical Materials Research Programs (DMR:TMRP)
Solicitation Number: NSF 23-612
Deadline: proposals accepted anytime
Description: Research supported by the Division of Materials Research (DMR) focuses on advancing the fundamental understanding of materials, materials discovery, design, synthesis, characterization, properties, and materials-related phenomena. DMR awards enable understanding of the electronic, atomic, and molecular structures, mechanisms, and processes that govern nanoscale to macroscale morphology and properties; manipulation and control of these properties; discovery of emerging phenomena of matter and materials; and creation of novel design, synthesis, and processing strategies that lead to new materials with unique characteristics. These discoveries and advancements transcend traditional scientific and engineering disciplines.

Mid-Career Advancement (MCA)
Solicitation Number: NSF 22-603
Deadline: Feb 1 - Mar 1, annually
Description: The MCA program offers an opportunity for scientists and engineers at the mid-career stage (see restrictions under Additional Eligibility Information) to substantively enhance and advance their research program and career trajectory. Mid-career scientists are at a critical career transition stage where they need to advance their research programs to ensure long-term productivity and creativity but are often constrained by service, teaching, or other activities that limit the amount of time devoted to research. MCA support is expected to help lift these constraints to reduce workload inequities and enable a more diverse scientific workforce (more women, persons with disabilities, and individuals from groups that have been underrepresented) at high academic ranks.

Division of Physics: Investigator-Initiated Research Projects (PHY)
Solicitation Number: NSF 23-615
Deadline: November and December, annually (deadlines vary by program)
Description: The Division of Physics (PHY) supports physics research and the preparation of future scientists in the nation’s colleges and universities across a broad range of physics disciplines that span scales of space and time from the largest to the smallest and the oldest to the youngest. The Division is comprised of disciplinary programs covering experimental and theoretical research in the following major subfields of physics: Atomic, Molecular and Optical Physics; Elementary Particle Physics; Gravitational Physics; Integrative Activities in Physics; Nuclear Physics; Particle Astrophysics; Physics at the Information Frontier; Physics of Living Systems; Plasma Physics; and Quantum Information Science. Principal Investigators (PIs) are encouraged to consider including specific efforts to increase diversity of the physics community and broaden participation of under-represented groups in Science, Technology, Engineering, and Mathematics (STEM).

Opportunities for Promoting Understanding through Synthesis (OPUS)
Solicitation Number: NSF 22-591
Deadline: Proposals Accepted Anytime
Description: The OPUS program is targeted to individuals, typically at later-career stages, who have contributed significant insights to a field or body of research over time. The program provides an opportunity to revisit and synthesize that prior research into a unique, integrated product(s) useful to the scientific community, now and in the future. All four clusters within the Division of Environmental Biology (Ecosystem Science, Evolutionary Processes, Population and Community Ecology, and Systematics and Biodiversity Science) encourage the submission of OPUS proposals.

Facilities for Atmospheric Research and Education (FARE)
Solicitation Number: PD 22-1529
Deadline: continuous
Description: TheTo facilitate fundamental research in the atmospheric sciences, the Division of Atmospheric and Geospace Sciences (AGS) supports state-of-the-art instruments and facilities through the Facilities for Atmospheric Research and Education (FARE) Program. The FARE Program includes the Lower Atmosphere Observing Facilities (LAOF) and the Community Instruments and Facilities (CIF).

Coupling, Energetics, and Dynamics of Atmospheric Regions
Solicitation Number: NSF 25-510
Deadline: March 05, 2025; First Wednesday in March, Annually Thereafter
Description: The Coupling, Energetics, and Dynamics of Atmospheric Regions (CEDAR) program is a broad-based research program with the goal of understanding the behavior of atmospheric regions from the middle atmosphere upward through the thermosphere and ionosphere into the exosphere in terms of coupling, energetics, chemistry, and dynamics on regional and global scales. These processes are related to the sources of perturbations that propagate upward from the lower atmosphere as well as to solar radiation and particle inputs from above. The activities within this program include observations from ground-based and space-based platforms, theory, and modeling.

Earth Sciences Instrumentation and Facilities
Solicitation Number: NSF 22-577
Deadline: Proposals accepted anytime
Description: The NSF Division of Earth Sciences (EAR) hereby solicits proposals for research infrastructure that is necessary to advance understanding of the Earth System including: the structure, properties and dynamics of the solid Earth and the interactions between the solid Earth and its biosphere, hydrosphere, cryosphere and atmosphere; the history and evolution of life; and the history and dynamics of Earth’s climate. The EAR Instrumentation and Facilities Program (EAR/IF) will support meritorious requests for instrument-based and human research infrastructure that will advance understanding of the Earth system, contribute toward training a diverse geoscience workforce, and encourage efforts to support belonging, accessibility, justice, equity, diversity, and inclusion (BAJEDI).

Biological Oceanography (BioOce)
Solicitation Number: PD 23-1650
Deadline: accepted continuously
Description: The Biological Oceanography Program supports fundamental research in biological oceanography and marine ecology (populations to the ecosystems) broadly defined: relationships among aquatic organisms and their interactions with the environments of the oceans or Great Lakes. Projects submitted to the program are often interdisciplinary efforts that may include participation by other OCE or BIO Programs.

Cyber-Physical Systems (CPS)
Solicitation Number: NSF 21-551
Deadline: SMALL and MEDIUM proposals: anytime; FRONTIER proposals: Aug 28, annually
Description: Cyber-physical systems (CPS) are engineered systems that are built from, and depend upon, the seamless integration of computation and physical components. Advances in CPS will enable capability, adaptability, scalability, resiliency, safety, security, and usability that will expand the horizons of these critical systems. The CPS program aims to develop the core research needed to engineer these complex CPS, some of which may also require dependable, high-confidence, or provable behaviors. Core research areas of the program include control, data analytics, and machine learning including real-time learning for control, autonomy, design, Internet of Things (IoT), mixed initiatives including human-in- or human-on-the-loop, networking, privacy, real-time systems, safety, security, and verification. By abstracting from the particulars of specific systems and application domains, the CPS program seeks to reveal cross-cutting, fundamental scientific and engineering principles that underpin the integration of cyber and physical elements across all application domains. The program additionally supports the development of methods, tools, and hardware and software components based upon these cross-cutting principles, along with validation of the principles via prototypes and testbeds. This program also fosters a research community that is committed to advancing education and outreach in CPS and accelerating the transition of CPS research into the real world.

WINDOWS ON THE UNIVERSE: THE ERA OF MULTI-MESSENGER ASTROPHYSICS (WoU-MMA)
Solicitation Number: PD 18-5115
Deadline: varies by field of study
Description: The NSF's Big Idea “Windows on the Universe” is implemented through this WoU-MMA program. WoU-MMA identifies three categories of messengers - electromagnetic waves, high-energy particles including neutrinos and cosmic rays, and gravitational waves. The goals of WoU-MMA are to build the capabilities and accelerate the synergy and interoperability of the three messengers to realize integrated, multi-messenger astrophysical explorations of the Universe. The WoU-MMA program welcomes proposals in any area of research supported through the participating divisions that address at least one of the following criteria: Coordination: Hardware, software, or other infrastructure to coordinate observations involving more than one messenger. Observations: Observations of astrophysical objects or phenomena that are potentially sources of more than one messenger, including the use of existing observatories, experiments, and data archives, as well as the development and construction of new capabilities for advancing multi-messenger astrophysics. Interpretation: Theory, experiment, simulations and other activities to understand or interpret observations of astrophysical objects that are sources of more than one messenger.

Computational Mathematics
Solicitation Number: PD 16-1271
Deadline: Submission window: November 16 - December 1, annually
Description: Supports mathematical research in areas where computation plays a central and essential role, emphasizing analysis, development, and implementation of theoretically justified and efficient algorithms. The combination of these elements resulting in innovative computational methods is a hallmark of the program. Proposals ranging from single investigator to interdisciplinary team projects that not only create and analyze new computational mathematics techniques but also implement them to model, study, and solve important application problems are strongly encouraged, as is providing opportunities for rigorous mathematical training of junior computational mathematicians through research involvement.

Facility and Instrumentation Request Process
Solicitation Number: NSF 23-602
Deadline: Anytime - Track 1 (Education & Outreach) & Track 2 (Single Facility Request)
Description: The Facility and Instrumentation Request Process (FIRP) solicitation describes the mechanism by which the research community can propose projects that require access to instrumentation and facilities sponsored by the Facilities for Atmospheric Research and Education (FARE) Program in the Division of Atmospheric and Geospace Sciences (AGS). FARE provides funding support to a variety of organizations to make specialized instrumentation and facilities available to the atmospheric science research community through the Lower Atmosphere Observing Facilities (LAOF) and the Community Instruments and Facilities (CIF) programs. FIRP allows for parallel evaluation of intellectual merit and broader impacts along with the feasibility of the proposed project. All research proposals and education and outreach proposals that require the use of FARE-sponsored assets must be submitted through this solicitation. PIs requesting the use of FARE-sponsored facilities for a scientific and/or educational project must follow the guidelines for submission in this solicitation. The FIRP solicitation offers three proposal submission tracks based on the type and purpose of the request: Track 1 - Education and Outreach. Track 2 - Single Facility Request. Track 3 - Field Campaigns. Preference for funding will be given to proposals submitted to programs in the Division of Atmospheric and Geospace Sciences in the Geosciences Directorate. If you are planning to submit a proposal to a program outside AGS, including NSF-wide or Directorate-wide solicitations and solicitations released under the NSF 10 Big Ideas, please contact the FARE program director to discuss the timelines, review process, and budget request for the use of FARE assets.

Joint DMS/NIGMS Initiative to Support Research at the Interface of the Biological and Mathematical Sciences (DMS/NIGMS)
Solicitation Number: NSF 22-600
Deadline: Sep 1 – Sep 18, annually
Description: The Division of Mathematical Sciences (DMS)in the Directorate for Mathematical and Physical Sciences (MPS) at the National Science Foundation (NSF)and the National Institute of General Medical Sciences (NIGMS) at the National Institutes of Health (NIH) plan to support fundamental research in mathematics and statistics necessary to answer questions in the biological and biomedical sciences. Both agencies recognize the need to promote research at the interface between mathematical and life sciences. This program is designed to encourage new collaborations, as well as to support innovative activities by existing teams.

Computational and Data-Enabled Science and Engineering (CDS&E)
Solicitation Number: PD 22-8084
Deadline: Sep 1 – Nov 15, annually (deadlines vary by division)
Description: Large-scale simulations and the ability to accumulate massive amounts of data have revolutionized science and engineering. The goal of the CDS&E meta-program is to identify and capitalize on opportunities for major scientific and engineering breakthroughs through new computational and data-analysis approaches and best practices. The CDS&E meta-program supports projects that harness computation and data to advance knowledge and accelerate discovery above and beyond the goals of the participating individual programs. The intellectual drivers may be in an individual discipline, or they may cut across more than one discipline in various Divisions and Directorates. A CDS&E proposal should enable and/or utilize development and adaptation of advances in research and infrastructure in computational and data science.

Computational and Data-Enabled Science and Engineering in Mathematical and Statistical Sciences (CDS&E-MSS)
Solicitation Number: PD 22-8069
Deadline: proposals accepted anytime
Description: The CDS&E-MSS program accepts proposals that engage with the mathematical and statistical challenges presented by (1) the ever-expanding role of computational experimentation, modeling, and simulation on the one hand, and (2) the explosion in production and analysis of digital data from experimental and observational sources on the other. The goal of the program is to promote the creation and development of the next generation of mathematical and statistical software tools, and the theory underpinning those tools, that will be essential for addressing these challenges.

Robert Noyce Teacher Scholarship Program
Solicitation Number: NSF 23-586
Deadline: Last Tuesday in August, Annually
Description: The National Science Foundation Robert Noyce Teacher Scholarship Program (Noyce) invites innovative proposals that address the critical need for recruiting, preparing, and retaining highly effective elementary and secondary mathematics and science teachers and teacher leaders in high-need school districts. To achieve this goal, Noyce supports talented science, technology, engineering, and mathematics (STEM) undergraduate majors and professionals to become effective K-12 STEM teachers. It also supports experienced, exemplary K-12 STEM teachers to become teacher leaders in high-need school districts. In addition, Noyce supports research on the effectiveness and retention of K-12 STEM teachers in high-need school districts. Noyce offers four program tracks: Track 1: The Robert Noyce Teacher Scholarships and Stipends (S&S) Track, Track 2: The NSF Teaching Fellowships (TF) Track, Track 3: The NSF Master Teaching Fellowships (MTF) Track, and Track 4: The Noyce Research Track. In addition, Capacity Building proposals are accepted from proposers intending to develop a proposal in any of the program's tracks.

Geoscience Opportunities for Leadership in Diversity
Solicitation Number: PD-21-178Y
Deadline: April 25, 2025; Oct 24, 2025
Description: The GOLD Program supports the mission of achieving greater and more systemic diversity by creating a network of champions who can generate greater implementation of evidence-based best practices and resources to promote belonging, accessibility, justice, equity, diversity and inclusion (BAJEDI) throughout the geoscience education, research enterprise and workforce. Supported projects will research and develop the complex interplay of environmental context, personal traits, and motivating factors that

Education Programs in Atmospheric and Geospace Sciences
Solicitation Number: PD-21-7700
Deadline: Proposals Accepted Anytime
Description: GSEducation supports efforts to integrate atmospheric and geospace research and education via two main program areas, which are:

1. Research Experiences for Undergraduates (REU) Site Program. This program provides funding to Universities andResearch Laboratories that allows them to offer summer internships to undergraduate students who would like to participate in atmospheric and/or geospace research efforts. Proposals may be submitted annually (August deadline).
2. AGS Postdoctoral Fellowships:AGS awards 2-year Postdoctoral Fellowships to highly qualified investigators within 3 years of obtaining their PhD to carry out an integrated program of independent research and education. While the postdoc program is funded by core programs, the AGS Education program supports the cost of professional development for the fellows.

Conferences and Workshops in the Mathematical Sciences
Solicitation Number: NSF 21-541
Deadline: Proposals Accepted Anytime
Description: Conferences, workshops, and related events (including seasonal schools and international travel by groups) support research and training activities of the mathematical sciences community. Proposals for conferences, workshops, or conference-like activities may request funding of any amount and for durations of up to three years. Proposals under this solicitation must select "Conference" as the proposal type, and they must be submitted to the appropriate DMS programs in accordance with the lead-time requirements, submission windows, or deadlines specified on the program web page. See the DMS Programs page and click on the appropriate program for program-specific information.

Sustaining Infrastructure for Biological Research
Solicitation Number: NSF 21-503
Deadline: Proposals accepted anytime
Description: The Sustaining Infrastructure for Biological Research (Sustaining) Program supports the continued operation of existing research infrastructure that advances contemporary biology in any research area supported by the Directorate for Biological Sciences (BIO)at NSF. The Sustaining Program focuses primarily on sustaining critical research infrastructure that is cyberinfrastructure or biological living stocks and that is broadly applicable to a wide range of researchers. Projects are expected to ensure continued availability of existing, mature resources that will enable important science outcomes achieved by users representing a broad range of research supported by BIO and its collaborating organizations.

Transitions to Excellence in Molecular and Cellular Biosciences Research (Transitions)
Solicitation Number: NSF 21-508
Deadline: Accepted anytime
Description: The Division of Molecular and Cellular Biosciences (MCB) has developed a new opportunity to enable researchers with a strong track record of prior accomplishment to pursue a new avenue of research or inquiry. This funding mechanism is designed to facilitate and promote a PI’s ability to effectively adopt empowering technologies that might not be readily accessible in the PI’s current research environment or collaboration network. Transformative research likely spans disciplines and minimizing the practical barriers to doing so will strengthen research programs poised to make significant contributions. The award is intended to allow mid-career or later-stage researchers (Associate or Full Professor, or equivalent) to expand or make a transition in their research programs via a sabbatical leave or similar mechanism of professional development and then develop that research program in their own lab. This award will also enable the PI to acquire new scientific or technical expertise, facilitate the investigator’s competitiveness, and potentially lead to transformational impacts in molecular and cellular bioscience. The award would fund up to six months of PI salary during the first sabbatical or professional development year, followed by support for continued research for two subsequent years upon the PI’s return to normal academic duties. Requests for flexibility in the timing of the sabbatical or professional development year will be considered with appropriate justification. Please contact the cognizant program director for the solicitation. Through this solicitation MCB and NSF hope to develop a novel mechanism that will encourage investigators to expand and/or transition to new research areas aligned with MCB priorities, to increase retention of investigators in science, and to ensure a diverse scientific workforce that remains engaged in active research.

Infrastructure Capacity for Biological Research
Solicitation: NSF-23-580
Sponsored by: NSF
Deadline: Accepted anytime
Description: The Infrastructure Capacity for Biological Research (Capacity) Program supports the implementation of, scaling of, or major improvements to research tools, products, and services that advance contemporary biology in any research area supported by the Directorate forBiological Sciences at NSF. The Capacity Program focuses on building capacity in research infrastructure that is broadly applicable to a wide range of researchers in three programmatic areas: Cyberinfrastructure, Biological Collections, and Biological Field Stations and Marine Laboratories. This program will also accept proposals for planning activities or workshops to facilitate coordination that may be necessary in building capacity in infrastructure that meets the needs of a research community. Areas not included in this program are instrumentation (PIs should submit to the MRI program) and, projects that develop infrastructure for a specific research project, laboratory, or institution (PIs should submitted to the relevant BIO programs that would normally support that research). Projects are expected to produce quality products, result in important science outcomes that will be achieved by the users of the resource, be openly accessible to a broad scientific and education community, and serve a community of researchers beyond a single research team.

Infrastructure Innovation for Biological Research (IIBR)
Solicitation: NSF-23-578
Sponsored by: NSF
Deadline: Accepted anytime
Description: The Infrastructure Innovation for Biological Research Program (Innovation) supports research to design novel or greatly improved research tools and methods that advance contemporary biology in any research area supported by the Directorate forBiological Sciences at NSF. The Innovation Program focuses on research infrastructure that is broadly applicable to researchers in three programmatic areas: Bioinformatics, Instrumentation, and Research Methods. Infrastructure supported by this program is expected to advance biological understanding by improving scientists’ abilities to manipulate, control, analyze, or measure critical aspects of biological systems, which can be essential for addressing important fundamental research questions. Proposals submitted to these programmatic areas can do one of three things to advance or transform research in biology: develop novel infrastructure, significantly redesign existing infrastructure, or adapt existing infrastructure in novel ways. Projects are expected to have a significant application to one or more biological science questions and have the potential to be used by a community of researchers beyond a single research team.

Biophotonics
Solicitation: PD 23-7236
Sponsored by: NSF
Deadline: Accepted anytime
Description: The goal of the Biophotonics program is to explore the research frontiers in photonics principles, engineering and technology that are relevant for critical problems in fields of medicine, biology and biotechnology. Fundamental engineering research and innovation in photonics is required to lay the foundations for new technologies beyond those that are mature and ready for application in medical diagnostics and therapies. Advances are needed in nanophotonics, optogenetics, contrast and targeting agents, ultra-thin probes, wide field imaging, and rapid biomarker screening. Low cost and minimally invasive medical diagnostics and therapies are key motivating application goals.

Antarctic Research Requiring U.S. Antarctic Program Support for Fieldwork
Solicitation: NSF 25-525
Sponsored by: NSF
Deadline: Concept Outline (required): January 15, Annually. Full proposal: June 1, Annually.
Description: Through this solicitation, the Antarctic Sciences Section (ANT) of the Office of Polar Programs (OPP) funds cutting-edge research that requires logistical support from the U.S. Antarctic Program (USAP) and: (1) Improves understanding of interactions among the Antarctic region and global systems. (2) Improves understanding of the dynamic linkages among processes operating in the Antarctic and Southern Ocean and linkages to global Earth systems, which helps inform decision making regarding environmental change. (3) Advances fundamental understanding of Earth systems and the biological, geochemical, and physical processes in the Antarctic and Southern Ocean as drivers and responders to changes on a global scale. (4) Expands fundamental knowledge of Antarctic systems, biota, and processes. (5) Utilizes the unique characteristics of the Antarctic region as a science observing platform. (6) Builds capacity and enhances diversity in the US workforce for polar-related science. Antarctic fieldwork is supported only for research that must be performed, or is best performed, in Antarctica.

Electrochemical Systems
Solicitation: PD 23-7644
Sponsored by: NSF
Deadline: Continuously accepted
Description: The  Electrochemical Systems program is part of the Chemical Process Systems cluster, which also includes: 1) the  Catalysis program; 2) the  Interfacial Engineering program; and 3) the  Process Systems, Reaction Engineering, and Molecular Thermodynamics program.

The goal of the Electrochemical Systems program is to support fundamental engineering research that will enable innovative processes involving electro- or photochemistry for the sustainable production of electricity, fuels, and chemicals. Processes for sustainable energy and chemical production must be scalable, environmentally benign, reduce greenhouse gas production, and utilize renewable resources. Research projects that stress fundamental understanding of phenomena that directly impact key barriers to improved system or component-level performance (for example, energy efficiency, product yield, process intensification) are encouraged. Processes for energy storage should address fundamental research barriers for the applications of renewable electricity storage or for transport propulsion. For projects concerning energy storage materials, proposals should involve hypotheses that involve device or component performance characteristics that are tied to fundamental understanding of transport, kinetics, or thermodynamics. Advanced chemistries are encouraged.

Proposed research should be inspired by the need for economic and impactful conversion processes. All proposal project descriptions should address how the proposed work, if successful, will improve process realization and economic feasibility and compare the proposed work against current state of the art. Highly integrated multidisciplinary projects are encouraged.

Current topics of interest include:
Electrochemical Energy and Chemical Production Systems
Organic Photovoltaics Devices and Processing

Nanoscale Interactions
Solicitation Number: PD 23-1179
Deadline: No Deadline - Proposals for this program will be accepted throughout the year.
Description: The Nanoscale Interactions program is part of the Environmental Engineering and Sustainability cluster, which also includes: 1) the Environmental Engineering program; and 2) the Environmental Sustainability program.

The goal of the Nanoscale Interactions program is to support research to advance fundamental and quantitative understanding of the interactions of nanomaterials and nanosystems with biological and environmental media.

Materials of interest include one- to three-dimensional nanostructures, heterogeneous nano-bio hybrid assemblies, dendritic and micelle structures, quantum dots, and other nanoparticles. Such nanomaterials and systems frequently exhibit novel physical, chemical, photonic, electronic, and biological behavior as compared to the bulk scale. Collaborative and interdisciplinary proposals are encouraged.

Division of Environmental Biology (DEB)
Solicitation Number: NSF 24-543
Deadline: Accepted anytime
Description: The Division of Environmental Biology (DEB) Core Track supports research and training on evolutionary and ecological processes acting at the level of populations, species, communities, and ecosystems. DEB encourages research that elucidates fundamental principles that identify and explain the unity and diversity of life and its interactions with the environment over space and time. Research may incorporate field, laboratory, or collection-based approaches; observational or manipulative studies; synthesis activities; phylogenetic discovery projects; or theoretical approaches involving analytical, statistical, or computational modeling. Proposals should be submitted to the core clusters (Ecosystem Sciences, Evolutionary Processes, Population and Community Ecology, and Systematics and Biodiversity Sciences).

Division of Integrative Organismal Systems Core Programs
Solicitation Number: NSF 24-546
Deadline: Accepted Anytime
Description: The Division of Integrative Organismal Systems (IOS) Core Programs Track supports research aimed at understanding why organisms are structured the way they are and function as they do. Areas of inquiry include, but are not limited to, developmental biology and the evolution of developmental processes, nervous system development, structure, modification, function, and evolution; biomechanics and functional morphology, physiological processes, symbioses and microbial interactions, interactions of organisms with biotic and abiotic environments, plant and animal genomics, and animal behavior. The IntBIO Track invites submission of collaborative proposals to tackle bold questions in biology that require an integrated approach to make substantive progress. Integrative biological research spans sub-disciplines and incorporates cutting-edge methods, tools, and concepts from each to produce groundbreaking biological discovery that is synergistic, such that the sum is greater than the parts.

Foundational Research in Robotics
Solicitation Number: PD-20-144Y
Deadline: Proposals accepted anytime
Description: The Foundational Research in Robotics (Robotics) program supports research on robotic systems that exhibit significant levels of both computational capability and physical complexity. For the purposes of this program, a robot is defined as intelligence embodied in an engineered construct, with the ability to process information, sense, and move within or substantially alter its working environment. Here intelligence includes a broad class of methods that enable a robot to solve problems or make contextually appropriate decisions. Research is welcomed that considers inextricably interwoven questions of intelligence, computation, and embodiment. Projects may also focus on a distinct aspect of intelligence, computation, or embodiment, as long as the proposed research is clearly justified in the context of a class of robots.

Re-entry to Active Research Program (RARE)
Solicitation Number: NSF-20-586
Sponsored by: NSF
Deadline: Anytime
Description: The Division of Chemical, Bioengineering, Environmental, and Transport Systems (CBET) and the Division of Chemistry (CHE) are conducting a Re-entry to Active Research (RARE) program to reengage, retrain, and broaden participation within the academic workforce. The primary objective of the RARE program is to catalyze the advancement along the academic tenure-track of highly meritorious individuals who are returning from a hiatus from active research. By providing re-entry points to active academic research, the RARE program will reinvest in the nation’s most highly trained scientists and engineers, while broadening participation and increasing diversity of experience. A RARE research proposal must describe potentially transformative research that falls within the scope of participating CBET or CHE programs.

Dear Colleague Letter: NSF ANR Chemistry Lead Agency Opportunity on Sustainable Chemistry: Catalysis with Earth-Abundant Elements
Solicitation Number: NSF 24-129
Deadline: An Expression of Interest (EOI) is required (no deadline, but must be approved prior to full proposal submission. Full proposal: June 2, 2025
Description: Among current sustainability challenges, the development of more sustainable catalysts or catalytic processes needs to be addressed to unlock the potential of many innovations. In this context, ANR and NSF aim to strengthen the research on catalysis with earth abundant elements by fostering collaborations and synergies between research teams in France and in the US. To this end, the scope of this call for proposals is fundamental research in homogeneous catalysis with Earth-abundant elements. It will include organometallic catalysis, organocatalysis, and photocatalysis. The focus of the proposals should be on advances related to the development of new catalysts and catalytic strategies and associated mechanistic and computational studies.

Dear Colleague Letter: Improving Undergraduate STEM Education – Adaptation, Implementation, and Dissemination (IUSE-AID)
Solicitation Number: NSF 24-026
Deadline: NA
Description: This DCL encourages STEM education communities to submit proposals to the Directorate for STEM Education’s Improving Undergraduate STEM Education (IUSE:EDU) program (NSF 23-510) that focus on Adaptation and Implementation, and/or Dissemination of proven teaching strategies and learning materials reflecting advances in what is known about undergraduate STEM teaching and learning. Proposals that develop faculty expertise, implement educational innovations, adapt existing educational innovations for specific teaching and learning environments, and disseminate teaching and learning innovations beyond the scale of the efforts that created them are encouraged. Potential project emphases: Adaptation and Implementation of Existing Instructional Strategies; Dissemination of Existing Instructional Strategies.

Dear Colleague Letter: Tool Development for Molecular and Cell Biology (Tools4Cells)
Solicitation Number: 23-121
Deadline: NA
Description: This DCL encourages submission of proposals to develop novel tools and methods that improve scientists’ abilities to measure, analyze, manipulate, or control critical aspects of cellular properties and functions in order to continue to push boundaries and open new avenues of inquiry in molecular and cellular biosciences.

Dear Colleague Letter: NSF and the Romanian Executive Agency for Higher Education, Research, Development and Innovation Funding (UEFISCDI) Lead Agency Opportunity in the Mathematical Sciences
Solicitation Number: NSF 24-125
Deadline: Varies by division
Description: The Division of Mathematical Sciences (DMS) within the Mathematical & Physical Sciences Directorate (MPS) of the National Science Foundation (NSF) and the Romanian Executive Agency for Higher Education, Research, Development and Innovation Funding (UEFISCDI) have created a partnership to support international collaboration under the NSF-UEFISCDI Lead Agency Opportunity in the Mathematical Sciences. The goal of this activity is to promote collaborative research within the mathematical sciences by reducing barriers to conducting research with international collaborators. The NSF-UEFISCDI Lead Agency Opportunity allows U.S. and Romanian researchers to submit a single collaborative proposal that will undergo a single merit review process through NSF as the lead agency.

Dear Colleague Letter: Interdisciplinary REU Sites at the Intersection of Computing and Communication Foundations and Mathematics and Statistics
Solicitation Number: NSF 23-082
Deadline: Varies by division
Description: REU projects involve students in meaningful ways in ongoing research programs or in research projects specifically designed for the REU program. The REU Sites program aims to provide appropriate and valuable educational experiences for undergraduate students through participation in research. Interdisciplinary REU sites offer the opportunity to bring together researchers and students from different disciplines to enable cross-fertilization and initiate new research directions. Interdisciplinary REU sites can also help to grow a new generation of students with unique skills to tackle important research problems of interest to both disciplines. The purpose of this Dear Colleague Letter (DCL) is to invite the submission of interdisciplinary REU Sites proposals that explore high impact topics at the intersection of Computing and Communication Foundations and Mathematics and Statistics to the REU program.

Dear Colleague Letter: High School Student Research Assistantships (MPS-High) Funding to Broaden Participation in the Mathematical and Physical Sciences
Solicitation Number: NSF 22-041
Deadline: Continuously accepted (AST, CHE, DMR, DMS, PHY, OMA)
Description: Inviting requests which foster interest in the pursuit of studies in the Mathematical and Physical Sciences; and broaden participation of high school students who are in groups that have been traditionally underrepresented and under-served in STEM fields.

Dear Colleague Letter: ANR - NSF/MCB/PHY Lead Agency Opportunity at the Molecular and Cellular Biosciences - Physics Interface
Solicitation Number: NSF 24-015
Deadline: no deadline
Description: The lead agency opportunity allows U.S. and French researchers to submit a single proposal describing a project involving U.S. and French researchers that will undergo a single review process by the lead agency, on behalf of NSF/MCB, NSF/PHY and ANR. The emergence, evolution, dynamics, and function of self-organized cellular systems stem from the interaction of biological components and the environment to yield robust, resilient, and adaptive living systems. Through this DCL, NSF and ANR seek proposals that use multidisciplinary approaches that emphasize quantitative, predictive and theory driven science aimed at understanding mechanisms underlying these essential life processes at the molecular, subcellular, and cellular scales. We are seeking proposals that integrate approaches from theoretical and experimental physics and biology to develop testable and quantitative understanding of biological questions. Projects providing innovative methodological or conceptual approaches to a biological question together with a strong theoretical physics component are strongly encouraged. Projects that leverage unique resources and capabilities of partners in the U.S. and France will be given priority.

Dear Colleague Letter: CHE FY22 International Supplement
Solicitation Number: NSF 22-070
Deadline: May 1 (annually)
Description: The Division of Chemistry is inviting requests for supplemental funding from its existing awardees who may wish to add a new, or strengthen an existing, international dimension of their research supported by an award from the Division, when an international collaboration advances the field of chemistry and enhances the U.S. investigator's own research and/or education objectives. Principal Investigators supported by NSF Division of Chemistry research awards are advised to consult with their cognizant NSF program director prior to submitting a supplemental funding request.

Dear Colleague Letter: NSF-DFG Lead Agency Opportunity in Molecular and Cellular Biology
Solicitation Number: NSF 22-015
Deadline: Proposals accepted continuously
Description: Recognizing the importance of international collaborations in promoting scientific discoveries, the US National Science Foundation (NSF) and the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) have signed a Memorandum of Understanding (MOU) on research cooperation. The MOU provides an overarching framework to encourage collaboration between US and German research communities and sets out the principles by which jointly supported activities might be developed. The MOU provides for a Lead Agency Opportunity whereby proposals may be submitted to either NSF or DFG. To facilitate the support of collaborative work between US researchers and their German counterparts, the Division of Molecular and Cellular Bioscience (BIO/MCB) at NSF and the Division of Molecular and Organismal Biology and Agriculture (MOBA) at DFG are pleased to announce a Lead Agency Opportunity in the area of Molecular and Cell Biology (NSF-DFG MolCellBio). The goal of this Opportunity is to help reduce some of the current barriers to working internationally. This Lead Agency Opportunity allows US and German researchers to develop and submit a single proposal to either NSF or DFG describing a project involving US and German researchers that will undergo a single review process by the designated Lead Agency. US and German collaborators are invited to submit joint proposals in the areas covered by NSF's BIO/MCB and DFG's review board 201 "Basic Research in Biology and Medicine." The proposals should focus on basic research at a molecular, subcellular or cellular level, including theoretical approaches.

Advanced Research Projects Agency for Health
Programs of interest:
Resilient Systems Office: Office-Wide Innovative Solutions Opening for Advanced Research Projects Agency for Health
Solicitation: ARPA-H-SOL-24-103
Application Deadline: March 14, 2025
Description: This ISO seeks solution summary and proposal submissions for projects that fall within the scope of the ARPA-H mission Resilient Systems Office (RSO). RSO’s interest areas will address systemic challenges across the healthcare and public health landscape by investing in cutting-edge technologies that address long-standing gaps in the quality, efficacy, and consistent availability of care.

Health Science Futures: Office-Wide Innovative Solutions Opening for Advanced Research Projects Agency for Health
Solicitation: ARPA-H-SOL-24-104
Application Deadline:  March 14, 2025
Description: This ISO seeks solution summaries and proposal submissions for projects that fall within the general scope of the ARPA-H Health Science Futures (HSF) mission office. HSF expands what is technically possible by developing approaches that will remove the scientific and technological limitations that stymie progress towards the healthcare of the future. HSF supports cutting-edge, often disease-agnostic research programs that have the potential for translational real-world change.

Scalable Solutions Office: Office-Wide Innovative Solutions Opening for Advanced Research Projects Agency for Health
Solicitation: ARPA-H-SOL-24-105
Application Deadline: March 14, 2025
Description: This ISO seeks solution summaries and proposals for projects that fall within the general scope of the ARPA-H Scalable Solutions mission office. SSO expands what is technically possible by developing approaches that will leverage an interdisciplinary approach and collaborative networks to address challenges of geography, distribution, manufacturing, data and information, thereby improving health care access and affordability. In the United States, many communities and remote areas lack access to timely and quality health care, which leads to disparities in health outcomes for those populations. Bottlenecks during the manufacturing processes of products and health technologies also lead to delays and limited availability, preventing effective distribution of health care solutions to areas of need, especially in emergencies.

Proactive Health Office: Office-Wide Innovative Solutions Opening for Advanced Research Projects Agency for Health
Solicitation: ARPA-H-SOL-24-106
Application Deadline: March 14, 2025
Description: The Proactive Health Office (PHO) at ARPA-H is seeking solutions to improve the healthspan and health outcomes of Americans prior to the onset of disease and/or the development of diminished quality of life from illness. Specifically, PHO hypothesizes that 1) population-level improvements in access to and uptake of disease prevention and wellness-promoting behaviors and 2) development of novel early-detection methods and prophylactic interventions could drastically improve the health of American throughout their lives, and 3) that system level innovations are required for delivery of proactive health effectively.

Early-stage Biomedical Data Repositories and Knowledgebases (R24 Clinical Trial Not Allowed)
Solicitation: PAR-23-236
Deadline: Standard due dates through Jan 25, 2026. LOI (strongly encouraged) due 60 days prior to the application due date.
Description: This program supports the development of early-stage or new data repositories or knowledgebases that could be valuable for the biomedical research community. The overall goal is to support pilot activities that demonstrate the need and potential impact of the data resource. The NOFO will also support transitioning resources that are currently supported as investigator-initiated research efforts into quality controlled, standards-based resources that address governance, and efficiency of operations. Efforts to consolidate existing data repositories or independent knowledgebases are also in scope for this NOFO.

Enhancement and Management of Established Biomedical Data Repositories and Knowledgebases (U24 Clinical Trial Not Allowed)
Solicitation: PAR-23-237
Deadline: Standard due dates through Jan 25, 2026. LOI (strongly encouraged) due 60 days prior to the application due date.
Description: This program supports established biomedical data resources that have demonstrated impact and have potential for continued benefit to the mission of one or more of the NIH Institutes and Centers participating in this announcement. Applications funded under this NOFO for established data resources must already exist, address the needs of the targeted biomedical research community, document scientific impact they have had thus far, and have potential for continued benefit to the community served. Applications appropriate for this NOFO can support data resources for biomedical research, spanning biological scales including molecular, cellular, tissue, organism, and/or population data, as well as social and behavioral data. Support for software and tool development must be limited to that which provides essential functions or significantly increases the efficiency of the resource operations. An application should distinctly support either a data repository or a knowledgebase. Resources that desire to support both should submit separate applications to ensure their proper review per the distinct review criteria.

Maximizing Investigators' Research Award (R35 - Clinical Trial Optional)
Solicitation: PAR-22-180
Deadline: January 16, 2025; May 16, 2025
Description: Supporting fundamental research by funding individual projects has a number of consequences that reduce the efficiency and effectiveness of the biomedical research enterprise in the U.S. To address these issues and increase the efficiency and efficacy of grant funding, the NIGMS Maximizing Investigators' Research Award (MIRA) is a single grant to provide support for the NIGMS-relevant program of research in an investigator's laboratory. For this FOA, the "program of research" is defined as a collection of projects in an investigator's laboratory that are within the mission of NIGMS.

Maximizing Investigators’ Research Award (MIRA) for Early Stage Investigators (ESI) (R35 - Clinical Trial Optional)
Solicitation: PAR-23-145
Deadline: February 03, 2025; October 03, 2025; February 03, 2026
Description: The Maximizing Investigators' Research Award provides support for a program of research in an early stage investigator's laboratory that falls within the mission of NIGMS. For the purpose of this NOFO, a program of research is a collection of projects in the investigator's lab that are relevant to the mission of NIGMS. The goal of MIRA is to increase the efficiency and efficacy of NIGMS funding.

Ruth L. Kirschstein National Research Service Award (NRSA) Individual Postdoctoral Fellowship (Parent F32)
Solicitation: PA-23-262
Deadline: Standard due dates through August 08, 2025
Description: Supports research training of highly promising postdoctoral candidates who have the potential to become productive, independent investigators in scientific health-related research fields relevant to the missions of the participating NIH Institutes and Centers. Applications are expected to incorporate exceptional mentorship. This Notice of Funding Opportunity (NOFO) is designed specifically for candidates proposing research that does not involve leading an independent clinical trial, a clinical trial feasibility study, or an ancillary clinical trial, but does allow candidates to propose research experience in a clinical trial led by a sponsor or co-sponsor.

Ruth L. Kirschstein National Research Service Award (NRSA) Individual Predoctoral Fellowship (Parent F31)
Solicitation: PA-23-272
Deadline: Apr 08, 2025; Aug 08, 2025
Description: The purpose of the Ruth L. Kirschstein National Research Service Award (NRSA) Individual Predoctoral Fellowship (Parent F31) award is to enable promising predoctoral students to obtain individualized, mentored research training from outstanding faculty sponsors while conducting dissertation research in scientific health-related fields relevant to the missions of the participating NIH Institutes and Centers. The proposed mentored research training must reflect the candidate’s dissertation research project and is expected to clearly enhance the individual’s potential to develop into a productive, independent research scientist.

Modern Equipment for Shared-use Biomedical Research Facilities: Advancing Research-Related Operations (S15 Clinical Trial Not Allowed)
Solicitation: PAR-24-259
Deadline: Sep 25, 2025; Sep 25, 2026
Description: This program invites eligible academic or research institutions to apply for funding support to purchase latest scientific equipment that will enhance and modernize research-supporting operations of existing shared biomedical research facilities. Targeted are laboratory research core facilities, animal research facilities, and other similar shared-use research spaces. The goal of this NOFO is to strengthen research-auxiliary activities of biomedical research facilities and to enhance the efficiency of their operations. The NOFO does not support the purchase of scientific research instruments or their components, nor components of building-level infrastructure equipment that indirectly support research activities.

Shared Instrumentation Grant (SIG) Program (S10 Clinical Trial Not Allowed)
Solicitation: Expect new NOFO in FY2025
Deadline: TBA
Description: The Shared Instrument Grant (SIG) Program encourages applications from groups of NIH-supported investigators to purchase or upgrade a single item of high-priced, specialized, commercially available instruments or integrated instrumentation system. The minimum award is $50,000. There is no maximum price limit for the instrument; however, the maximum award is $600,000. Instruments supported include, but are not limited to: X-ray diffractometers, mass spectrometers, nuclear magnetic resonance spectrometers, DNA and protein sequencers, biosensors, electron and light microscopes, flow cytometers, and biomedical imagers.

Basic Instrumentation Grant (BIG) Program (S10 Clinical Trial Not Allowed)
Solicitation: PAR-24-326
Deadline: June 02, 2025; June 01, 2026; June 01, 2027
Description: The Basic Instrumentation Grant (BIG) Program encourages applications from groups of NIH-supported investigators to purchase a single piece of new, costly, specialized, commercially available instrument or an integrated instrumentation system. The minimum award is $25,000. There is no maximum price limit for the instrument; however, the maximum award is $350,000. Instruments supported include, but are not limited to, basic cell sorters, confocal microscopes, ultramicrotomes, gel imagers, or computer systems.

High-End Instrumentation (HEI) Grant Program (S10 Clinical Trial Not Allowed)
Solicitation: PAR-24-264
Deadline: June 02, 2025; June 01, 2026; June 01, 2027
Description: The High-End Instrumentation (HEI) Grant Program encourages applications from groups of NIH-supported investigators to purchase or upgrade a single item of high-end, specialized, commercially available instruments or integrated systems. The minimum award is $600,001. There is no maximum price limit for the instrument; however, the maximum award is $2,000,000. Instruments supported include, but are not limited to, X-ray diffractometers, high throughput robotic screening systems, mass spectrometers, nuclear magnetic resonance spectrometers, DNA and protein sequencers, biosensors, electron and light microscopes, flow cytometers, and biomedical imagers.

Development of Resources and Technologies for Enhancing Rigor, Reproducibility, and Translatability of Animal Models in Biomedical Research (R24 Clinical Trials Not Allowed)
Solicitation: PAR-23-039
Deadline: Standard due dates through May 25, 2025
Description: The Office of Research Infrastructure Programs (ORIP) encourages resource-related research grant applications aimed at developing broadly applicable technologies, tools, and resources for validating animal models and enhancing rigor, reproducibility, and translatability of animal research. Proposed studies, models, resources, or technologies submitted under this Funding Opportunity Announcement (FOA) must either address research interests of multiple NIH Institutes and Centers (ICs), explore multiple organ systems, or be applicable to diseases and processes that impact multiple organ systems in order to align with ORIP’s NIH-wide mission and programs. Applications should aim to enhance the rigor, reproducibility, and translatability of animal research through the development of technologies, tools, and resources that have significant impact across a broad range of research areas using animal models. Applications must demonstrate how the proposed resources and technologies impact rigor and reproducibility of animal studies.

Imaging, Biomarkers and Digital Pathomics for the Early Detection of Premetastatic Cancer and Precancerous Lesions Associated with Lethal Phenotypes (R01 Clinical Trial Optional)
Solicitation: PAR-22-131
Deadline: NIH standard due dates through June 5, 2025
Description: This FOA supports the development of state-of-the-art projects that integrate imaging, biomarkers, digital pathomics, glycomics, metabolomics, other omic information and/or meta data obtained from platforms including but not limited to lower resolution diagnostic acquisitions and systemic biomarker results to high resolution single-cell analytics / imaging applied to the characterization of heterogeneous cell populations within tumor for improving current approaches for: (1) the early detection of organ confined premetastatic aggressive cancer, and, (2) identifying precancerous lesions associated with the development of a subsequent lethal phenotype. This FOA specifically attempts to address and improve diagnostic uncertainty in clinical decisions by improving detection sensitivity and specificity of integrated multiparametric platforms.

NEW Individual Investigator Research Awards for Prevention and Early Detection
Solicitation: RFA R-26.1-IIRAP
Deadline: May 06, 2025
Description: Supports applications which propose clinical and population-based projects designed to develop effective prevention and early detection interventions to reduce cancer risk, mortality, and morbidity among Texans. Projects that propose such research collaborations with existing CPRIT Prevention Program awardees including the CPRIT funded Texas Collaborative Center for Hepatocellular Cancer and cancer survivorship research to enhance the health and well-being of all cancer survivors and caregivers, are strongly encouraged. Award: Up to $300,000 per year for a period of up to 4 years.

NEW Individual Investigator Research Awards for Early-Onset Cancers
Solicitation: RFA R-26.1-IIRA-EOC
Deadline: May 06, 2025
Description: Supports innovative research projects that will significantly advance the knowledge of the etiology, prevention, cancer biology, and treatment of early-onset cancers. Award: Up to $300,000 per year for period of up to 3 years.

NEW Investigator Research Awards for Computational and Systems Biology of Cancer
Solicitation: RFA R-26.1-IIRACSBC
Deadline: May 06, 2025
Description: Supports applications for innovative mathematical and/or computational research projects addressing questions that will advance current knowledge in the (a) mechanisms that tie altered gene expression and downstream molecular mechanisms to functional cancer phenotypes and/or (b) mechanisms that tie tumor morphology to functional cancer phenotypes and/or mechanisms that tie treatment sequence and combination to evolving functional cancer phenotypes (that emerge as a result of treatment selection). Award: Up to $350,000 per year for a period of up to 3 years.

NEW Individual Investigator Research Awards for Cancer in Children and Adolescents
Solicitation: RFA R-26.1-IIRACCA
Deadline: May 06, 2025
Description: Supports applications for innovative research projects addressing questions that will advance knowledge of the causes, prevention, progression, detection, or treatment of cancer in children and adolescents. Laboratory, clinical, or population-based studies are all acceptable. CPRIT expects the outcome of the research to reduce the incidence, morbidity, or mortality from cancer in children and/or adolescents in the near- or long-term. Award: Up to $300,000 per year for a period of up to 4 years.

NEW Individual Investigator Research Awards
Solicitation: RFA R-26.1-IIRA
Deadline: May 06, 2025
Description: Supports applications for innovative research projects addressing critically important questions that will significantly advance knowledge of the causes, prevention, and/or treatment of cancer. Areas of interest include laboratory research, translational studies, and/or clinical investigations. Award: Up to $300,000 per year for a period of up to 3 years.

Simons Foundation: Collaborations in Mathematics and the Physical Sciences
Sponsor: Simon’s Foundation
Deadline: LOI: October 31, 2024; Full proposal: February 25, 2025
Description: This program aims to stimulate progress on fundamental scientific questions of major importance in mathematics, theoretical physics, and theoretical computer science. A Simons Collaboration in MPS should address a mathematical or theoretical topic of fundamental scientific importance, where a significant, new development creates a novel area for exploration or provides a new direction for progress in an established field.

Glenn W. Bailey Foundation: STEM Program Grants
Sponsor: Glenn W. Bailey Foundation
Deadline: LOIs are accepted at any time
Description: The Foundation offers awards to support postsecondary STEM programming, including opportunities to expand on current programs or seed money to create new programs. Funding can support many activities and initiatives such as club activities, career management counselors, showcases, research projects, camps, tech talks, student clubs and organizations, lecture series, and professor continuing education programs.

Targeted Grants in Mathematics and Physical Sciences
Sponsor: Simons Foundation
Deadline: Continuously accepted (LOI required)
Description: The program is intended to support high-risk theoretical mathematics, physics and computer science projects of exceptional promise and scientific importance on a case-by-case basis.

American Chemical Society Petroleum Research Fund
Sponsor: American Chemical Society
Deadline: March 7, 2025
Description: The Petroleum Research Fund supports fundamental research directly related to petroleum or fossil fuels. ACS PRF grants are intended as seed money, to enable an investigator to initiate a new research direction. The investigator should not have published or received financial support from another funding agency for the proposed research. Proposals must be for fundamental research in “the petroleum field,” which is defined in our founding document as “petroleum, natural gas, coal, shale, tar sands and like materials.” ACS PRF funds two programs: New Directions and Doctoral New Investigator.

Damon Runyon Fellowship Award
Sponsor: Damon Runyon Cancer Research Foundation
Deadline: March 15, 2025
Description: The Foundation encourages all theoretical and experimental research relevant to the study of cancer and the search for cancer causes, mechanisms, therapies and prevention. Candidates must apply for the fellowship under the guidance of a Sponsor—a scientist (tenured, tenure-track or equivalent position) capable of providing mentorship to the Fellow.

Kleberg Foundation - Medical Research
Sponsor: Robert J. Kleberg Jr. and Helen C. Kleberg Foundation
Deadline: March 31; September 30
Description: The Foundation is seeking highly innovative and groundbreaking medical research proposals from top tier institutions in both basic biological and applied research that will have the greatest impact on scientific knowledge and human health. Proposals should be distinctive and novel in their approaches, question the prevailing paradigm, and lead to advancement of knowledge in the field.

Whitehall Foundation Grant Programs
Sponsor: Whitehall Foundation
Deadline: LOIs: Jan 15, Apr 15, Oct 1. Full applications: Jun 1, Sep 1, Feb 15
Description: The Whitehall Foundation aims to support scholarly research in the life sciences that are not heavily supported by federal agencies or other foundations with specialized missions. The foundation emphasizes the support of young scientists at the beginning of their careers and productive senior scientists who wish to move into new fields of interest. The Foundation is currently interested in basic research in neurobiology, defined as follows: Invertebrate and vertebrate (excluding clinical) neurobiology, specifically investigations of neural mechanisms involved in sensory, motor, and other complex functions of the whole organism as these relate to behavior. The overall goal should be to better understand behavioral output or brain mechanisms of behavior. The Foundation does not support research focused primarily on disease(s) unless it will also provide insights into normal functioning.

National Center and Team Science Planning Award
Sponsor: University of Houston
Deadline: Applications accepted through August 31, 2025, or until the funds are exhausted
Description: President Khator’s Research Preeminence: 50-in-5 initiative calls for a doubling of our national centers from the current five centers to ten centers over the next five years. Applying for a center grant is a major effort. In recognition of this effort, the Division of Research (DOR) is offering internal planning grants to prepare for a center grant application. The funding is intended to provide up to 18 months of support to teams of researchers led by a University of Houston (UH) faculty member to prepare for the submission of a proposal to a targeted funding opportunity.

Equipment Grants
Sponsor: University of Houston
Deadline: December 2, 2024
Description: The purpose of the Equipment Grants program is to support research labs and groups with modern equipment considered necessary for preparing competitive external research proposals. About 70% of the awards will be allocated for proposals in UH’s research priority areas. Another 30% will be for any relevant area selected by an investigator. Proposals will be considered for small equipment grants and can range up to $50,000.

Grants to Enhance and Advance Research (GEAR)
Sponsor: University of Houston
Deadline: Pre-proposal: November 1, 2025 (expected); Full proposal: January 24, 2026 (expected)
Description: The GEAR program seeks bold new ideas, showing clear evidence of a high likelihood of securing extramural grant funding in the short term and viability as a research program in the long-term. The GEAR program is not a supplement to currently funded research projects or to new faculty startup funds. Faculty members with current funding who are developing new areas of research are encouraged to apply provided they can demonstrate a clear distinction between the proposed research and their currently funded research lines.

High Priority Area Research Seed Grants
Sponsor: University of Houston
Deadline: February 21, 2025
Description: The purpose of the Seed Grants program is to provide research labs and groups with funds that would permit submission of competitive research proposals. The Seed Grants program is closely tied to institutional research priorities. Formation of interdisciplinary research teams is encouraged to build capabilities to address these complex issues.