Alexander V. Statsyuk

Associate Professor of Medicinal Chemistry
Department of Pharmacological and Pharmaceutical Sciences

Office: 
University of Houston College of Pharmacy
Health 2, Room 7037
4349 Martin Luther King Boulevard
Houston, TX 77204-5039

Contact: avstatsyuk@uh.edu - Office: 713-743-9616 - Fax: 713-743-1884

Research:

Research projects in the Statsyuk laboratory use chemistry to illuminate mechanisms of human diseases, and to develop novel therapeutic modalities to treat them. Our research group is highly interdisciplinary and encompasses chemistry, protein & structural biochemistry, enzymology, cell biology, pharmacokinetics, and drug discovery. The research projects are highly collaborative in nature. Our drug discovery efforts focus on developing ultra-selective and ultra-potent drugs that affect only disease tissues but not normal tissues, and therefore have no side effects. Ultra-selectivity is achieved by designing drugs that target specific disease mutations, by targeting specific receptors present in the disease cells, by using ternary pharmacology approaches (i.e. designing drugs that bind the receptor with the help of the disease tissue specific helper proteins), antibody-drug conjugates, natural products, as well as covalent protein and small molecule drugs. Specific projects are as follows (more details can be found in my LinkedIn profile):

1. Biochemistry and Pharmacology of the Ubiquitin System.
2. Covalent drug discovery technologies.
3. Covalent protein drugs.
4. Treating protein misfolding diseases.
5. Ternary pharmacology to drug the undruggable.
6. Antibody-drug conjugates.
7. Targeting cancer genes and signaling networks using FBDD and natural products.