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College of Pharmacy

College of Pharmacy

Faculty Profile

Bin GuoRongjin Sun

Research Assistant Professor of Pharmaceutics
Department of Pharmacological and Pharmaceutical Sciences

Office: 
University of Houston College of Pharmacy
Health 2, Room 5011
4349 Martin Luther King Boulevard
Houston, TX 77204-5037

Contact: rsun5@uh.edu

Research:

  • Mechanisms, biomarkers, and prevention of Drug-induced liver/intestinal toxicity
  • Manipulate the local bioavailability of drug candidates or drugs for improved efficacy and reduced side effects via regulation of the transporters and enzymes
  • Studying the pharmacokinetic characterization of drugs and deploying PK/PD modeling analysis and biostatistics services for potential anti-cancer drugs
  • Ph.D. in Pharmacology, Guangzhou University of Chinese Medicine, Guangzhou, China
  • Master of Pharmacy, College of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Jiangxi, China
  • Bachelor in Pharmacy, Hubei University of Medicine, Hubei, China

NCBI Profile
  • Wang C, Teng a X, Wang C, Liu B, Zhou R, Xu X, Qiu H, Fu Y, Sun R, Liang Z, Zhang R, Liu Z, Zhang L, Zhu L. 2023. Insight into the Mechanism of Xiao-Chai-Hu-Tang Alleviates Irinotecan-Induced Diarrhea Based on Regulating the Gut Microbiota and Inhibiting Gut β-GUS. Phytomedicine, 155040. https://doi.org/https://doi.org/10.1016/j.phymed.2023.155040
  • Zheng Z, Srinual S, Chen J, Li L, Du T, Hu M, Sun R*, Gao S*. Herbal Medicines as adjuvants for the treatment of chemotherapy-induced diarrhea. Curr Drug Metab. 2023 Aug 17. doi: 10.2174/1389200224666230817102224. Epub ahead of print. PMID: 37592799.
  • Lu F, Cai H, Li S, Xie W, Sun R*. The Chemical Signatures of Water Extract of Zingiber officinale Rosc. Molecules. 2022 Nov 13;27(22). doi: 10.3390/molecules27227818.PubMed PMID: 36431919; PubMed Central PMCID: PMC9696620.
  • Zhou J, He X, Sun R, Yu Z, Wang C, Deng S, Zhang B, Huang S, Han C, Li D. Lignans from Bupleurum marginatum and their antioxidant activity. Nat Prod Res. 2022 Oct;36(19):5016-5021. doi: 10.1080/14786419.2021.1917570. Epub 2021 Apr 28. PubMed PMID: 33908316
  • Gao S, Sun R, Singh R, Yu So S, Chan CTY, Savidge T, Hu M. The role of gut microbial β-glucuronidase in drug disposition and development. Drug Discov Today. 2022 Oct;27(10):103316. doi: 10.1016/j.drudis.2022.07.001. Epub 2022 Jul 9. Review. PubMed PMID: 35820618; PubMed Central PMCID: PMC9717552
  • Li L, Sun R, Zenga J, Himburg H, Wang L, Duan S, Liu J, Bui D, Xie Z, Du T, Xie L, Yin T, Wong S, Gao S, Hu M. Comparison of Absolute Expression and Turnover Number of COX-1 and COX-2 in Human and Rodent Cells and Tissues. J Inflamm Res. 2022;15:4435-4447. doi: 10.2147/JIR.S365842. eCollection 2022. PubMed PMID: 35958187; PubMed Central PMCID: PMC9359786
  • Du T, Sun R (co-author), Etim I, Zheng Z, Liang D, Hu M, Gao S. Age-and Region-Dependent Disposition of Raloxifene in Rats. Pharm Res. 2021 Aug;38(8):1357-1367. doi: 10.1007/s11095-021-03084-y. Epub 2021 Jul 28. PubMed PMID: 34322833; PubMed Central PMCID: PMC8452384
  • Du T, Sun R (co-author),Siddiqui N, Moatamed L, Zhang Y, Liang D, Hu M, Gao S. A positive-negative switching LC-MS/MS method for quantification of fenoldopam and its phase II metabolites: Applications to a pharmacokinetic study in rats. J Chromatogr B Analyt Technol Biomed Life Sci. 2021 Aug 1;1179:122854. doi: 10.1016/j.jchromb.2021.122854. Epub 2021 Jul 5. PubMed PMID: 34242859; PubMed Central PMCID: PMC8403159
  • Du T, Sun R (co-author), Li L, Ebuzoeme C, Bui D, Zheng Z, Yin T, Liang D, Hu M, Gao S. Development and validation of ultra-high-performance liquid chromatography-mass spectrometry method for the determination of raloxifene and its phase II metabolites in plasma: Application to pharmacokinetic studies in rats. J Sep Sci. 2020 Dec;43(24):4414-4423. doi: 10.1002/jssc.202000835. Epub 2020 Nov 20. PubMed PMID: 33119204; PubMed Central PMCID: PMC8452178
  • Zhou J, Wen J, Huang J, Chen P, Ma X, Sun R, Wang C. Aromatic Rosane-type Diterpenoid with Lipase Inhibitory Effect from Euphorbia ebracteolata and Chemotaxonomic Significance of Diterpenoids. Records of Natural Products. 2020 October; 15(3):202-206. doi: 10.25135/rnp.204.20.08.1774.
  • Sun R, Chen M, Hu Y, et al. CYP3A4/ 5 mediates the metabolic detoxification of humantenmine, a highly toxic alkaloid from Gelsemium elegans Benth. J Appl Toxicol. 2019;1–10. https://doi.org/10.1002/jat.3813
  • Li Y, Song W, Ou X, Luo G, Xie Y, Sun R, Wang Y, Qi X, Hu M, Liu Z, Zhu L. Breast Cancer Resistance Protein and Multidrug Resistance Protein 2 Determine the Disposition of Esculetin-7-O-Glucuronide and 4-Methylesculetin-7-O-Glucuronide. Drug Metab Dispos. 2019 Mar;47(3):203-214. doi: 10.1124/dmd.118.083493. Epub 2019 Jan 2. PubMed PMID: 30602435
  • Wang L, Sun R, Zhang Q, Luo Q, Zeng S, Li X, Gong X, Li Y, Lu L, Hu M, Liu Z. An update on polyphenol disposition via coupled metabolic pathways. Expert Opin Drug Metab Toxicol. 2019 Feb;15(2):151-165. doi: 10.1080/17425255.2019.1559815. Epub 2018 Dec 24. Review. PubMed PMID: 30583703
  • Sun R, Basu S, Zeng M, Hu M, Gao S. Xiao-Chai-Hu-Tang (XCHT) Intervening Irinotecan’s Disposition: The Potential of XCHT in Alleviating Irinotecan-Induced Diarrhea. Current Cancer Drug Targets. 2018 September 28; 19:1-10. DOI:10.2174/1568009618666181029153255
  • Zeng M, Sun R (co-author), Basu S, Ma Y, Ge S, Yin T, Gao S, Zhang J, Hu M. Disposition of flavonoids via recycling: Direct biliary excretion of enterically or extrahepatically derived flavonoid glucuronides. Mol Nutr Food Res. 2016 May;60(5):1006-19. doi: 10.1002/mnfr.201500692. Epub 2016 Apr 13. PubMed PMID: 26843117
  • Sun R, Zeng M, Du T, Li L, Yang G, Hu M, Gao S. Simultaneous determinations of 17 marker compounds in Xiao-Chai-Hu-Tang by LC-MS/MS: Application to its pharmacokinetic studies in mice. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Oct 15;1003:12-21. doi: 10.1016/j.jchromb.2015.09.004. Epub 2015 Sep 11. PubMed PMID: 26397748
  • Yang G, Gao S, Sun R, Yin T, Hu M. Development and validation of an UPLC-MS/MS method for the quantification of columbin in biological matrices: Applications to absorption, metabolism, and pharmacokinetic studies. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Oct 1;1002:13-8. doi: 10.1016/j.jchromb.2015.07.030. Epub 2015 Aug 7. PubMed PMID: 26295697
  • Ma Y, Zeng M, Sun R, Hu M. Disposition of flavonoids impacts their efficacy and safety. Curr Drug Metab. 2014;15(9):841-64. Review. PubMed PMID: 25658129

Awards & Honors

  • Outstanding Teacher of the University, Hubei University of Medicine, 2014
  • Second Prizes of City Scientific and Technological Progress Award, Shiyan, China, 2013
  • Second prize in the school "Teaching Excellence Award" competition, Hubei University of Medicine, 2012